Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)

Open Access

Peer-reviewed

Research Article

Ying Wang,

Affiliation Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Jin-jian Lu,

Affiliations Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China, College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, People's Republic of China
⨯
Li He,

Affiliation Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Qiang Yu

* E-mail: qyu@sibs.ac.cn

Affiliation Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯

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Phosphorylation
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HeLa cells
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DNA damage
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Cancers and neoplasms
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DNA transcription
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Cancer treatment
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Small interfering RNA
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Transfection
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