Direct Semi-Synthesis of the Anticancer Lead-Drug Protoapigenone from Apigenin, and Synthesis of Further New Cytotoxic Protoflavone Derivatives

• Attila Hunyadi ,

  Contributed equally to this work with: Attila Hunyadi, Da-Wei Chuang

  Affiliations Institute of Pharmacognosy, University of Szeged, Szeged, Hungary, Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Da-Wei Chuang ,

  Contributed equally to this work with: Attila Hunyadi, Da-Wei Chuang

  Affiliation Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Balazs Danko,

  Affiliation Institute of Pharmacognosy, University of Szeged, Szeged, Hungary

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• Michael Y. Chiang,

  Affiliation Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan

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• Chia-Lin Lee,

  Affiliation Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan

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• Hui-Chun Wang,

  Affiliation Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Chin-Chung Wu,

  Affiliation Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Fang-Rong Chang ,

  * E-mail: aaronfrc@kmu.edu.tw (FRC); yachwu@mail.cmu.edu.tw (YCW)

  Affiliations Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Research and Development Center of Chinese Herbal Medicines and New Drugs, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Yang-Chang Wu

  * E-mail: aaronfrc@kmu.edu.tw (FRC); yachwu@mail.cmu.edu.tw (YCW)

  Affiliations Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan, Natural Medicinal Products Research Center, China Medical University Hospital, Taichung, Taiwan

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