Rationally Designed Interfacial Peptides Are Efficient In Vitro Inhibitors of HIV-1 Capsid Assembly with Antiviral Activity

Rebeca Bocanegra; María Nevot; Rosa Doménech; Inmaculada López; Olga Abián; Alicia Rodríguez-Huete; Claudio N. Cavasotto; Adrián Velázquez-Campoy; Javier Gómez; Miguel Ángel Martínez; José Luis Neira; Mauricio G. Mateu

doi:10.1371/journal.pone.0023877

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Peer-reviewed

Research Article

Rationally Designed Interfacial Peptides Are Efficient In Vitro Inhibitors of HIV-1 Capsid Assembly with Antiviral Activity

Rebeca Bocanegra,

Affiliation Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain
⨯
María Nevot,

Affiliation Fundació IrsiCaixa, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
⨯
Rosa Doménech,

Affiliation Centro de Biología Molecular y Celular, Universidad Miguel Hernández, Elche, Alicante, Spain
⨯
Inmaculada López,

Affiliation Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain
⨯
Olga Abián,

Affiliations Institute for Biocomputation and Physics of Complex Systems, Zaragoza, Spain, Aragon Health Sciences Institute, CIBERed, Zaragoza, Spain
⨯
Alicia Rodríguez-Huete,

Affiliation Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain
⨯
Claudio N. Cavasotto,

Affiliation School of Health Information Sciences, The University of Texas Health Science Center at Houston, Texas, United States of America
⨯
Adrián Velázquez-Campoy,

Affiliations Institute for Biocomputation and Physics of Complex Systems, Zaragoza, Spain, Fundación ARAID, Diputación General de Aragón, Zaragoza, Spain
⨯
Javier Gómez,

Affiliation Centro de Biología Molecular y Celular, Universidad Miguel Hernández, Elche, Alicante, Spain
⨯
Miguel Ángel Martínez,

Affiliation Fundació IrsiCaixa, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
⨯
José Luis Neira,

Affiliations Centro de Biología Molecular y Celular, Universidad Miguel Hernández, Elche, Alicante, Spain, Institute for Biocomputation and Physics of Complex Systems, Zaragoza, Spain
⨯
Mauricio G. Mateu

* E-mail: mgarcia@cbm.uam.es

Affiliation Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain
⨯

Rationally Designed Interfacial Peptides Are Efficient In Vitro Inhibitors of HIV-1 Capsid Assembly with Antiviral Activity

Rebeca Bocanegra,
María Nevot,
Rosa Doménech,
Inmaculada López,
Olga Abián,
Alicia Rodríguez-Huete,
Claudio N. Cavasotto,
Adrián Velázquez-Campoy,
Javier Gómez,
Miguel Ángel Martínez

Published: September 8, 2011
https://doi.org/10.1371/journal.pone.0023877

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