Loss of Cytoplasmic CDK1 Predicts Poor Survival in Human Lung Cancer and Confers Chemotherapeutic Resistance

Chunyu Zhang; Abdel G. Elkahloun; Matthew Robertson; Joell J. Gills; Junji Tsurutani; Joanna H. Shih; Junya Fukuoka; M. Christine Hollander; Curtis C. Harris; William D. Travis; Jin Jen; Phillip A. Dennis

doi:10.1371/journal.pone.0023849

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Open Access

Peer-reviewed

Research Article

Loss of Cytoplasmic CDK1 Predicts Poor Survival in Human Lung Cancer and Confers Chemotherapeutic Resistance

Chunyu Zhang,

Current address: COPD program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Abdel G. Elkahloun,

Affiliation Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Matthew Robertson,

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Joell J. Gills,

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Junji Tsurutani,

Affiliations Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Medical Oncology Department, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan
⨯
Joanna H. Shih,

Affiliation Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Junya Fukuoka,

Affiliations Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Surgical Pathology, Toyama University Hospital, Toyama, Japan
⨯
M. Christine Hollander,

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Curtis C. Harris,

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
William D. Travis,

Affiliation Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Jin Jen,

Affiliations Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Phillip A. Dennis

* E-mail: dennisp@mail.nih.gov

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Loss of Cytoplasmic CDK1 Predicts Poor Survival in Human Lung Cancer and Confers Chemotherapeutic Resistance

Chunyu Zhang,
Abdel G. Elkahloun,
Matthew Robertson,
Joell J. Gills,
Junji Tsurutani,
Joanna H. Shih,
Junya Fukuoka,
M. Christine Hollander,
Curtis C. Harris,
William D. Travis

Published: August 24, 2011
https://doi.org/10.1371/journal.pone.0023849

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Non-small cell lung cancer
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Cytoplasmic staining
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Lung and intrathoracic tumors
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Gene expression
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Nuclear staining
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Apoptosis
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Microarrays
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Cell immortalization
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