High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model

Open Access

Peer-reviewed

Research Article

Joost Schulte ,

* E-mail: jschulte@mit.edu

Affiliation Department of Biology, Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Katharine J. Sepp,

Affiliation Department of Biology, Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Chaohong Wu,

Affiliation Department of Computer Science, National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts, United States of America
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Pengyu Hong,

Affiliation Department of Computer Science, National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts, United States of America
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J. Troy Littleton

Affiliation Department of Biology, Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Neurites
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Drosophila melanogaster
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RNA interference
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Toxicity
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Huntington disease
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Small molecules
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Neuronal morphology
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Library screening
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