High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22

Zheng Wang; Ling Yang; Yuhui Jiang; Zhi-Qiang Ling; Zhigang Li; Yuan Cheng; Heng Huang; Lingdi Wang; Yi Pan; Zhenzhen Wang; Xiaoqiang Yan; Yan Chen

doi:10.1371/journal.pone.0023737

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Open Access

Peer-reviewed

Research Article

High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22

Zheng Wang ,

Contributed equally to this work with: Zheng Wang, Ling Yang

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Ling Yang ,

Contributed equally to this work with: Zheng Wang, Ling Yang

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Yuhui Jiang,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Zhi-Qiang Ling,

Affiliation Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou, China
⨯
Zhigang Li,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Yuan Cheng,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Heng Huang,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Lingdi Wang,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Yi Pan,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Zhenzhen Wang,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯
Xiaoqiang Yan,

Affiliation Generon Corporation, Zhang Jiang Hi-Tech Park, Shanghai, China
⨯
Yan Chen

* E-mail: ychen3@sibs.ac.cn

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
⨯

High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22

Zheng Wang,
Ling Yang,
Yuhui Jiang,
Zhi-Qiang Ling,
Zhigang Li,
Yuan Cheng,
Heng Huang,
Lingdi Wang,
Yi Pan,
Zhenzhen Wang

Published: August 29, 2011
https://doi.org/10.1371/journal.pone.0023737

Reader Comments (2)

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14 Sep 2011
04:01 GMT
Most Recent

It is a high fat diet Posted by ychen99 on 14 Sep 2011 at 04:01 GMT
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29 Aug 2011
22:23 GMT
Most Recent

Not a true high fat diet Posted by jkiefer on 29 Aug 2011 at 22:23 GMT

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Adipose tissue
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Mouse models
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Genetically modified animals
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Liposarcoma
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Adipocytes
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Cancers and neoplasms
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Diet
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