Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats

Li-Dong Zhao; Wei-Wei Guo; Chang Lin; Li-Xian Li; Jian-He Sun; Nan Wu; Li-Li Ren; Xin-Xin Li; Hui-Zhan Liu; Wie-Yen Young; Wei-Qiang Gao; Shi-Ming Yang

doi:10.1371/journal.pone.0023729

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Open Access

Peer-reviewed

Research Article

Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats

Li-Dong Zhao ,

Contributed equally to this work with: Li-Dong Zhao, Wei-Wei Guo, Chang Lin, Li-Xian Li

Affiliation Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
⨯
Wei-Wei Guo ,

Contributed equally to this work with: Li-Dong Zhao, Wei-Wei Guo, Chang Lin, Li-Xian Li

Affiliation Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
⨯
Chang Lin ,

Contributed equally to this work with: Li-Dong Zhao, Wei-Wei Guo, Chang Lin, Li-Xian Li

Affiliation Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, China
⨯
Li-Xian Li ,

Contributed equally to this work with: Li-Dong Zhao, Wei-Wei Guo, Chang Lin, Li-Xian Li

Affiliations Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China, Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, China
⨯
Jian-He Sun,

Affiliation Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
⨯
Nan Wu,

Affiliation Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
⨯
Li-Li Ren,

Affiliation Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
⨯
Xin-Xin Li,

Affiliation Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
⨯
Hui-Zhan Liu,

Affiliation Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
⨯
Wie-Yen Young,

Affiliation Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
⨯
Wei-Qiang Gao ,

* E-mail: yangsm301@263.net (S-MY); weiqgao@yahoo.com (W-QG)

Affiliations Renji-MedX Clinical Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Shi-Ming Yang

* E-mail: yangsm301@263.net (S-MY); weiqgao@yahoo.com (W-QG)

Affiliation Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
⨯

Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats

Li-Dong Zhao,
Wei-Wei Guo,
Chang Lin,
Li-Xian Li,
Jian-He Sun,
Nan Wu,
Li-Li Ren,
Xin-Xin Li,
Hui-Zhan Liu,
Wie-Yen Young

Published: October 20, 2011
https://doi.org/10.1371/journal.pone.0023729

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