A Signature in HIV-1 Envelope Leader Peptide Associated with Transition from Acute to Chronic Infection Impacts Envelope Processing and Infectivity

Mohammed Asmal; Ina Hellmann; Weimin Liu; Brandon F. Keele; Alan S. Perelson; Tanmoy Bhattacharya; S. Gnanakaran; Marcus Daniels; Barton F. Haynes; Bette T. Korber; Beatrice H. Hahn; George M. Shaw; Norman L. Letvin

doi:10.1371/journal.pone.0023673

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Open Access

Peer-reviewed

Research Article

A Signature in HIV-1 Envelope Leader Peptide Associated with Transition from Acute to Chronic Infection Impacts Envelope Processing and Infectivity

Mohammed Asmal ,

* E-mail: masmal@bidmc.harvard.edu

Affiliation Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Ina Hellmann,

Affiliation Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Weimin Liu,

Affiliation Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Brandon F. Keele,

Affiliation Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Alan S. Perelson,

Affiliation Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
⨯
Tanmoy Bhattacharya,

Affiliations Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Santa Fe Institute, Santa Fe, New Mexico, United States of America
⨯
S. Gnanakaran,

Affiliation Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
⨯
Marcus Daniels,

Affiliation Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
⨯
Barton F. Haynes,

Affiliation Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Bette T. Korber,

Affiliations Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Santa Fe Institute, Santa Fe, New Mexico, United States of America
⨯
Beatrice H. Hahn,

Affiliation Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
George M. Shaw,

Affiliation Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Norman L. Letvin

Affiliation Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

A Signature in HIV-1 Envelope Leader Peptide Associated with Transition from Acute to Chronic Infection Impacts Envelope Processing and Infectivity

Mohammed Asmal,
Ina Hellmann,
Weimin Liu,
Brandon F. Keele,
Alan S. Perelson,
Tanmoy Bhattacharya,
S. Gnanakaran,
Marcus Daniels,
Barton F. Haynes,
Bette T. Korber

Published: August 18, 2011
https://doi.org/10.1371/journal.pone.0023673

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