An Integrated Drosophila Model System Reveals Unique Properties for F14512, a Novel Polyamine-Containing Anticancer Drug That Targets Topoisomerase II

Sonia Chelouah; Caroline Monod-Wissler; Christian Bailly; Jean-Marc Barret; Nicolas Guilbaud; Stéphane Vispé; Emmanuel Käs

doi:10.1371/journal.pone.0023597

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Research Article

An Integrated Drosophila Model System Reveals Unique Properties for F14512, a Novel Polyamine-Containing Anticancer Drug That Targets Topoisomerase II

Sonia Chelouah,

Current address: Institut de Cancérologie Gustave Roussy, Signalisation, Noyaux et Innovations en Cancérologie, UMR 8126 CNRS, Villejuif, France

Affiliations Université de Toulouse, UPS, Université Paul Sabatier, Laboratoire de Biologie Moléculaire Eucaryote; Toulouse; France, CNRS, Centre National de la Recherche Scientifique, UMR5099, Laboratoire de Biologie Moléculaire Eucaryote, Toulouse, France
⨯
Caroline Monod-Wissler,

Current address: Université de Toulouse 3, Centre de Biologie du Développement UMR5547 CNRS, Toulouse, France

Affiliations Université de Toulouse, UPS, Université Paul Sabatier, Laboratoire de Biologie Moléculaire Eucaryote; Toulouse; France, CNRS, Centre National de la Recherche Scientifique, UMR5099, Laboratoire de Biologie Moléculaire Eucaryote, Toulouse, France
⨯
Christian Bailly,

Affiliation Centre de Recherche en Oncologie Expérimentale, Institut de Recherche Pierre Fabre, Toulouse, France
⨯
Jean-Marc Barret,

Affiliation Centre de Recherche en Oncologie Expérimentale, Institut de Recherche Pierre Fabre, Toulouse, France
⨯
Nicolas Guilbaud,

Affiliation Centre de Recherche en Oncologie Expérimentale, Institut de Recherche Pierre Fabre, Toulouse, France
⨯
Stéphane Vispé ,

* E-mail: kas@ibcg.biotoul.fr (EK); stephane.vispe@pierre-fabre.com (SV)

Affiliation Centre de Recherche en Oncologie Expérimentale, Institut de Recherche Pierre Fabre, Toulouse, France
⨯
Emmanuel Käs

* E-mail: kas@ibcg.biotoul.fr (EK); stephane.vispe@pierre-fabre.com (SV)

Affiliations Université de Toulouse, UPS, Université Paul Sabatier, Laboratoire de Biologie Moléculaire Eucaryote; Toulouse; France, CNRS, Centre National de la Recherche Scientifique, UMR5099, Laboratoire de Biologie Moléculaire Eucaryote, Toulouse, France
⨯

An Integrated Drosophila Model System Reveals Unique Properties for F14512, a Novel Polyamine-Containing Anticancer Drug That Targets Topoisomerase II

Sonia Chelouah,
Caroline Monod-Wissler,
Christian Bailly,
Jean-Marc Barret,
Nicolas Guilbaud,
Stéphane Vispé,
Emmanuel Käs

Published: August 10, 2011
https://doi.org/10.1371/journal.pone.0023597

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Drosophila melanogaster
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Eyes
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Larvae
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DNA cleavage
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