NF-κB Inducing Kinase, NIK Mediates Cigarette Smoke/TNFα-Induced Histone Acetylation and Inflammation through Differential Activation of IKKs

Sangwoon Chung; Isaac K. Sundar; Jae-Woong Hwang; Fiona E. Yull; Timothy S. Blackwell; Vuokko L. Kinnula; Michael Bulger; Hongwei Yao; Irfan Rahman

doi:10.1371/journal.pone.0023488

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Peer-reviewed

Research Article

NF-κB Inducing Kinase, NIK Mediates Cigarette Smoke/TNFα-Induced Histone Acetylation and Inflammation through Differential Activation of IKKs

Sangwoon Chung,

Affiliation Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Isaac K. Sundar,

Affiliation Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Jae-Woong Hwang,

Affiliation Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Fiona E. Yull,

Affiliation Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Timothy S. Blackwell,

Affiliations Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Vuokko L. Kinnula,

Affiliation Pulmonary Division, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
⨯
Michael Bulger,

Affiliation Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Hongwei Yao,

Affiliation Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Irfan Rahman

* E-mail: Irfan_Rahman@urmc.rochester.edu

Affiliation Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York, United States of America
⨯

NF-κB Inducing Kinase, NIK Mediates Cigarette Smoke/TNFα-Induced Histone Acetylation and Inflammation through Differential Activation of IKKs

Sangwoon Chung,
Isaac K. Sundar,
Jae-Woong Hwang,
Fiona E. Yull,
Timothy S. Blackwell,
Vuokko L. Kinnula,
Michael Bulger,
Hongwei Yao,
Irfan Rahman

Published: August 24, 2011
https://doi.org/10.1371/journal.pone.0023488

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Histones
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Histone acetylation
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Chronic obstructive pulmonary disease
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