Activation of Toll-Like Receptor 3 Impairs the Dengue Virus Serotype 2 Replication through Induction of IFN-β in Cultured Hepatoma Cells

Zhaoduan Liang; Siyu Wu; Yuye Li; Li He; Minhao Wu; Lifang Jiang; Lianqiang Feng; Ping Zhang; Xi Huang

doi:10.1371/journal.pone.0023346

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Peer-reviewed

Research Article

Activation of Toll-Like Receptor 3 Impairs the Dengue Virus Serotype 2 Replication through Induction of IFN-β in Cultured Hepatoma Cells

Zhaoduan Liang ,

Contributed equally to this work with: Zhaoduan Liang, Siyu Wu

Affiliations Department of Immunology, Institute of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Siyu Wu ,

Contributed equally to this work with: Zhaoduan Liang, Siyu Wu

Affiliations Department of Immunology, Institute of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Yuye Li,

Affiliations Department of Immunology, Institute of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Li He,

Affiliations Department of Immunology, Institute of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Minhao Wu,

Affiliations Department of Immunology, Institute of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Lifang Jiang,

Affiliations Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China, Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Lianqiang Feng,

Affiliations Department of Immunology, Institute of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Ping Zhang ,

* E-mail: huangxi6@mail.sysu.edu.cn (XH); zhangp36@mail.sysu.edu.cn (PZ)

Affiliations Department of Immunology, Institute of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Xi Huang

* E-mail: huangxi6@mail.sysu.edu.cn (XH); zhangp36@mail.sysu.edu.cn (PZ)

Affiliations Department of Immunology, Institute of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯

Activation of Toll-Like Receptor 3 Impairs the Dengue Virus Serotype 2 Replication through Induction of IFN-β in Cultured Hepatoma Cells

Zhaoduan Liang,
Siyu Wu,
Yuye Li,
Li He,
Minhao Wu,
Lifang Jiang,
Lianqiang Feng,
Ping Zhang,
Xi Huang

Published: August 4, 2011
https://doi.org/10.1371/journal.pone.0023346

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Dengue virus
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Viral replication
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Toll-like receptors
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Interferons
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Immune receptor signaling
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Dengue fever
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Hepatoma cells
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