Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1

Maki Koyanagi; Shun-ichiro Asahara; Tomokazu Matsuda; Naoko Hashimoto; Yutaka Shigeyama; Yuki Shibutani; Ayumi Kanno; Megumi Fuchita; Tomoko Mikami; Tetsutya Hosooka; Hiroshi Inoue; Michihiro Matsumoto; Masato Koike; Yasuo Uchiyama; Tetsuo Noda; Susumu Seino; Masato Kasuga; Yoshiaki Kido

doi:10.1371/journal.pone.0023238

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Peer-reviewed

Research Article

Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1

Maki Koyanagi,

Affiliation Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Shun-ichiro Asahara,

Affiliation Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Tomokazu Matsuda,

Affiliation Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Naoko Hashimoto,

Affiliation Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Yutaka Shigeyama,

Affiliation Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Yuki Shibutani,

Affiliation Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Ayumi Kanno,

Affiliation Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Megumi Fuchita,

Affiliation Kobe University Graduate School of Health Sciences, Kobe, Japan
⨯
Tomoko Mikami,

Affiliation Kobe University Graduate School of Health Sciences, Kobe, Japan
⨯
Tetsutya Hosooka,

Affiliation Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Hiroshi Inoue,

Affiliation Frontier Science Organization, Kanazawa University, Kanazawa, Japan
⨯
Michihiro Matsumoto,

Affiliation Research Institute National Center for Global Health and Medicine, Tokyo, Japan
⨯
Masato Koike,

Affiliation Department of Cell Biology and Neurosciences, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Yasuo Uchiyama,

Affiliation Department of Cell Biology and Neurosciences, Juntendo University Graduate School of Medicine, Tokyo, Japan
⨯
Tetsuo Noda,

Affiliation Department of Cell Biology, Cancer Institute, Japanese Foundation of Cancer Research, Tokyo, Japan
⨯
Susumu Seino,

Affiliations Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan, Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Masato Kasuga,

Affiliation Research Institute National Center for Global Health and Medicine, Tokyo, Japan
⨯
[ ... ],
Yoshiaki Kido

* E-mail: kido@med.kobe-u.ac.jp

Affiliations Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan, Kobe University Graduate School of Health Sciences, Kobe, Japan
⨯
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Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1

Maki Koyanagi,
Shun-ichiro Asahara,
Tomokazu Matsuda,
Naoko Hashimoto,
Yutaka Shigeyama,
Yuki Shibutani,
Ayumi Kanno,
Megumi Fuchita,
Tomoko Mikami,
Tetsutya Hosooka

Published: August 19, 2011
https://doi.org/10.1371/journal.pone.0023238

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Mitochondria
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Insulin
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Insulin secretion
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Glucose
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Mitochondrial DNA
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Small interfering RNA
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Gene expression
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Genetically modified animals
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