Evidence for a Two-Metal-Ion Mechanism in the Cytidyltransferase KdsB, an Enzyme Involved in Lipopolysaccharide Biosynthesis

• Helgo Schmidt ,

  Contributed equally to this work with: Helgo Schmidt, Jeroen R. Mesters

  Current address: MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

  Affiliation Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany

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• Jeroen R. Mesters ,

  Contributed equally to this work with: Helgo Schmidt, Jeroen R. Mesters

  Affiliation Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany

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• Jing Wu,

  Current address: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China

  Affiliation Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, United States of America

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• Ronald W. Woodard,

  Affiliation Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, United States of America

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• Rolf Hilgenfeld ,

  * E-mail: hilgenfeld@biochem.uni-luebeck.de (RH); umamat@fz-borstel.de (UM)

  Affiliations Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany, Laboratory for Structural Biology of Infection and Inflammation, DESY, Hamburg, Germany, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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• Uwe Mamat

  * E-mail: hilgenfeld@biochem.uni-luebeck.de (RH); umamat@fz-borstel.de (UM)

  Affiliation Division of Structural Biochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany

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