HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)

Catarina E. Hioe; Michael Tuen; Gaia Vasiliver-Shamis; Yelina Alvarez; Kathleen C. Prins; Sagarika Banerjee; Arthur Nádas; Michael W. Cho; Michael L. Dustin; Scott C. Kachlany

doi:10.1371/journal.pone.0023202

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Peer-reviewed

Research Article

HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)

Catarina E. Hioe ,

* E-mail: catarina.hioe@nyumc.org

Affiliation Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, Manhattan Campus, New York, New York, United States of America
⨯
Michael Tuen,

Affiliation Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, Manhattan Campus, New York, New York, United States of America
⨯
Gaia Vasiliver-Shamis,

Affiliation Program in Molecular Pathogenesis, Marty and Helen Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, United States of America
⨯
Yelina Alvarez,

Affiliation Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, Manhattan Campus, New York, New York, United States of America
⨯
Kathleen C. Prins,

Affiliations Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, Manhattan Campus, New York, New York, United States of America, Program in Molecular Pathogenesis, Marty and Helen Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, United States of America
⨯
Sagarika Banerjee,

Affiliation Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, Manhattan Campus, New York, New York, United States of America
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Arthur Nádas,

Affiliation Department of Environmental Medicine, New York University School of Medicine, New York, New York, United States of America
⨯
Michael W. Cho,

Affiliation Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America
⨯
Michael L. Dustin,

Affiliation Program in Molecular Pathogenesis, Marty and Helen Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, United States of America
⨯
Scott C. Kachlany

Affiliations Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America, Actinobac Biomed, Incorporated, North Brunswick, New Jersey, United States of America
⨯

HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)

Catarina E. Hioe,
Michael Tuen,
Gaia Vasiliver-Shamis,
Yelina Alvarez,
Kathleen C. Prins,
Sagarika Banerjee,
Arthur Nádas,
Michael W. Cho,
Michael L. Dustin,
Scott C. Kachlany

Published: August 5, 2011
https://doi.org/10.1371/journal.pone.0023202

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