MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection

Leonardo A. de Almeida; Natalia B. Carvalho; Fernanda S. Oliveira; Thais L. S. Lacerda; Anilton C. Vasconcelos; Lucas Nogueira; Andre Bafica; Aristóbolo M. Silva; Sergio C. Oliveira

doi:10.1371/journal.pone.0023135

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Open Access

Peer-reviewed

Research Article

MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection

Leonardo A. de Almeida,

Affiliation Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais, Brazil
⨯
Natalia B. Carvalho,

Affiliation Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais, Brazil
⨯
Fernanda S. Oliveira,

Affiliation Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais, Brazil
⨯
Thais L. S. Lacerda,

Affiliation Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais, Brazil
⨯
Anilton C. Vasconcelos,

Affiliation Department of Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais, Brazil
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Lucas Nogueira,

Affiliation Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis-Santa Catarina, Brazil
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Andre Bafica,

Affiliation Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis-Santa Catarina, Brazil
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Aristóbolo M. Silva,

Affiliation Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais, Brazil
⨯
Sergio C. Oliveira

* E-mail: scozeus@icb.ufmg.br

Affiliation Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais, Brazil
⨯

MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection

Leonardo A. de Almeida,
Natalia B. Carvalho,
Fernanda S. Oliveira,
Thais L. S. Lacerda,
Anilton C. Vasconcelos,
Lucas Nogueira,
Andre Bafica,
Aristóbolo M. Silva,
Sergio C. Oliveira

Published: August 2, 2011
https://doi.org/10.1371/journal.pone.0023135

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Immune receptor signaling
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