Molecular Interaction of TPPP with PrP Antagonized the CytoPrP-Induced Disruption of Microtubule Structures and Cytotoxicity

Rui-Min Zhou; Yuan-Yuan Jing; Yan Guo; Chen Gao; Bao-Yun Zhang; Cao Chen; Qi Shi; Chan Tian; Zhao-Yun Wang; Han-Shi Gong; Jun Han; Bian-Li Xu; Xiao-Ping Dong

doi:10.1371/journal.pone.0023079

Loading metrics

Open Access

Peer-reviewed

Research Article

Molecular Interaction of TPPP with PrP Antagonized the CytoPrP-Induced Disruption of Microtubule Structures and Cytotoxicity

Rui-Min Zhou,

Affiliations State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China, Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan Province, People's Republic of China
⨯
Yuan-Yuan Jing,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯
Yan Guo,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯
Chen Gao,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯
Bao-Yun Zhang,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯
Cao Chen,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯
Qi Shi,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯
Chan Tian,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯
Zhao-Yun Wang,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯
Han-Shi Gong,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯
Jun Han,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯
Bian-Li Xu,

Affiliation Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan Province, People's Republic of China
⨯
Xiao-Ping Dong

* E-mail: dongxp238@sina.com

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China
⨯

Molecular Interaction of TPPP with PrP Antagonized the CytoPrP-Induced Disruption of Microtubule Structures and Cytotoxicity

Rui-Min Zhou,
Yuan-Yuan Jing,
Yan Guo,
Chen Gao,
Bao-Yun Zhang,
Cao Chen,
Qi Shi,
Chan Tian,
Zhao-Yun Wang,
Han-Shi Gong

Published: August 12, 2011
https://doi.org/10.1371/journal.pone.0023079

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Microtubules
Is the Subject Area "Microtubules" applicable to this article?

Thanks for your feedback.
Recombinant proteins
Is the Subject Area "Recombinant proteins" applicable to this article?

Thanks for your feedback.
Hamsters
Is the Subject Area "Hamsters" applicable to this article?

Thanks for your feedback.
Scrapie
Is the Subject Area "Scrapie" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Tubulins
Is the Subject Area "Tubulins" applicable to this article?

Thanks for your feedback.
Cytotoxicity
Is the Subject Area "Cytotoxicity" applicable to this article?

Thanks for your feedback.
Immunoprecipitation
Is the Subject Area "Immunoprecipitation" applicable to this article?

Thanks for your feedback.