Secreted Human Amyloid Precursor Protein Binds Semaphorin 3a and Prevents Semaphorin-Induced Growth Cone Collapse

Margaret H. Magdesian; Matthias Gralle; Luiz H. Guerreiro; Paulo José I. Beltrão; Milena M. V. F. Carvalho; Luís Eduardo da S. Santos; Fernando G. de Mello; Ricardo A. M. Reis; Sérgio T. Ferreira

doi:10.1371/journal.pone.0022857

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Open Access

Peer-reviewed

Research Article

Secreted Human Amyloid Precursor Protein Binds Semaphorin 3a and Prevents Semaphorin-Induced Growth Cone Collapse

Margaret H. Magdesian ,

Contributed equally to this work with: Margaret H. Magdesian, Matthias Gralle

* E-mail: magdesian@bioqmed.ufrj.br (MHM); gralle@bioqmed.ufrj.br (MG)

Affiliation Institute of Medical Biochemistry, Program in Biochemistry and Cellular Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Matthias Gralle ,

Contributed equally to this work with: Margaret H. Magdesian, Matthias Gralle

* E-mail: magdesian@bioqmed.ufrj.br (MHM); gralle@bioqmed.ufrj.br (MG)

Affiliation Institute of Medical Biochemistry, Program in Biochemistry and Cellular Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Luiz H. Guerreiro,

Affiliation Institute of Medical Biochemistry, Program in Biochemistry and Cellular Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Paulo José I. Beltrão,

Affiliation Institute of Medical Biochemistry, Program in Biochemistry and Cellular Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Milena M. V. F. Carvalho,

Affiliation Institute of Medical Biochemistry, Program in Biochemistry and Cellular Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Luís Eduardo da S. Santos,

Affiliation Institute of Biophysics Carlos Chagas Filho, Program in Neurobiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Fernando G. de Mello,

Affiliation Institute of Biophysics Carlos Chagas Filho, Program in Neurobiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Ricardo A. M. Reis,

Affiliation Institute of Biophysics Carlos Chagas Filho, Program in Neurobiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Sérgio T. Ferreira

Affiliation Institute of Medical Biochemistry, Program in Biochemistry and Cellular Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯

Secreted Human Amyloid Precursor Protein Binds Semaphorin 3a and Prevents Semaphorin-Induced Growth Cone Collapse

Margaret H. Magdesian,
Matthias Gralle,
Luiz H. Guerreiro,
Paulo José I. Beltrão,
Milena M. V. F. Carvalho,
Luís Eduardo da S. Santos,
Fernando G. de Mello,
Ricardo A. M. Reis,
Sérgio T. Ferreira

Published: July 29, 2011
https://doi.org/10.1371/journal.pone.0022857

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