Biologic Phenotyping of the Human Small Airway Epithelial Response to Cigarette Smoking

Ann E. Tilley; Timothy P. O'Connor; Neil R. Hackett; Yael Strulovici-Barel; Jacqueline Salit; Nancy Amoroso; Xi Kathy Zhou; Tina Raman; Larsson Omberg; Andrew Clark; Jason Mezey; Ronald G. Crystal

doi:10.1371/journal.pone.0022798

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Open Access

Peer-reviewed

Research Article

Biologic Phenotyping of the Human Small Airway Epithelial Response to Cigarette Smoking

Ann E. Tilley,

Affiliations Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, New York, United States of America
⨯
Timothy P. O'Connor,

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America
⨯
Neil R. Hackett,

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America
⨯
Yael Strulovici-Barel,

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America
⨯
Jacqueline Salit,

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America
⨯
Nancy Amoroso,

Affiliation Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, New York, United States of America
⨯
Xi Kathy Zhou,

Affiliation Department of Public Health, Weill Cornell Medical College, New York, New York, United States of America
⨯
Tina Raman,

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America
⨯
Larsson Omberg,

Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America
⨯
Andrew Clark,

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
⨯
Jason Mezey,

Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America
⨯
Ronald G. Crystal

* E-mail: geneticmedicine@med.cornell.edu

Affiliations Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, New York, United States of America
⨯

Biologic Phenotyping of the Human Small Airway Epithelial Response to Cigarette Smoking

Ann E. Tilley,
Timothy P. O'Connor,
Neil R. Hackett,
Yael Strulovici-Barel,
Jacqueline Salit,
Nancy Amoroso,
Xi Kathy Zhou,
Tina Raman,
Larsson Omberg,
Andrew Clark

Published: July 28, 2011
https://doi.org/10.1371/journal.pone.0022798

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Gene expression
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Chronic obstructive pulmonary disease
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Epithelium
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Smoking habits
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Transcriptome analysis
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Microarrays
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Singular value decomposition
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Phenotypes
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