Native-State Stability Determines the Extent of Degradation Relative to Secretion of Protein Variants from Pichia pastoris

Open Access

Peer-reviewed

Research Article

Graham Whyteside,

Affiliation School of Biology, University of Nottingham, Nottingham, United Kingdom
⨯
Marcos J. C. Alcocer,

Affiliation School of Biosciences, University of Nottingham, Sutton Bonington, United Kingdom
⨯
Janet R. Kumita,

Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
⨯
Christopher M. Dobson,

Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
⨯
Maria Lazarou,

Affiliations School of Biology, University of Nottingham, Nottingham, United Kingdom, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Richard J. Pleass,

Affiliations School of Biology, University of Nottingham, Nottingham, United Kingdom, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
David B. Archer

* E-mail: david.archer@nottingham.ac.uk

Affiliation School of Biology, University of Nottingham, Nottingham, United Kingdom
⨯

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Gene expression
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Lysozyme
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Protein folding
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Messenger RNA
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Protein secretion
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Secretion
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DNA transcription
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Yeast
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