DNA Immunization with Fusion of CTLA-4 to Hepatitis B Virus (HBV) Core Protein Enhanced Th2 Type Responses and Cleared HBV with an Accelerated Kinetic

Ying Yin; Chunchen Wu; Jingjiao Song; Junzhong Wang; Ejuan Zhang; Hongyan Liu; Dongliang Yang; Xinwen Chen; Mengji Lu; Yang Xu

doi:10.1371/journal.pone.0022524

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Open Access

Peer-reviewed

Research Article

DNA Immunization with Fusion of CTLA-4 to Hepatitis B Virus (HBV) Core Protein Enhanced Th2 Type Responses and Cleared HBV with an Accelerated Kinetic

Ying Yin ,

Contributed equally to this work with: Ying Yin, Chunchen Wu

Affiliation Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Chunchen Wu ,

Contributed equally to this work with: Ying Yin, Chunchen Wu

Affiliation Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
⨯
Jingjiao Song,

Affiliation Division of Clinical Immunology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
⨯
Junzhong Wang,

Affiliation Division of Clinical Immunology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
⨯
Ejuan Zhang,

Affiliation Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Hongyan Liu,

Affiliation Institute of Virology, University Hospital of Essen, Essen, Germany
⨯
Dongliang Yang,

Affiliation Division of Clinical Immunology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
⨯
Xinwen Chen,

Affiliation Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
⨯
Mengji Lu,

Affiliations Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Virology, University Hospital of Essen, Essen, Germany
⨯
Yang Xu

* E-mail: orangexuyang@hotmail.com

Affiliation Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯

DNA Immunization with Fusion of CTLA-4 to Hepatitis B Virus (HBV) Core Protein Enhanced Th2 Type Responses and Cleared HBV with an Accelerated Kinetic

Ying Yin,
Chunchen Wu,
Jingjiao Song,
Junzhong Wang,
Ejuan Zhang,
Hongyan Liu,
Dongliang Yang,
Xinwen Chen,
Mengji Lu,
Yang Xu

Published: July 22, 2011
https://doi.org/10.1371/journal.pone.0022524

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