Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans

Yiyuan Yuan; Pengxiu Cao; Mark A. Smith; Kristopher Kramp; Ying Huang; Naoki Hisamoto; Kunihiro Matsumoto; Maria Hatzoglou; Hui Jin; Zhaoyang Feng

doi:10.1371/journal.pone.0022354

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Peer-reviewed

Research Article

Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans

Yiyuan Yuan,

Affiliation Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Pengxiu Cao,

Affiliation Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Mark A. Smith,

Affiliation Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Kristopher Kramp,

Affiliation Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Ying Huang,

Affiliation Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Naoki Hisamoto,

Affiliation Department of Molecular Biology, Graduate School of Science, Institute for Advanced Research, Nagoya Solution-Oriented Research for Science and Technology, Japan Science and Technology Corporation, Chikusa-ku, Nagoya, Japan
⨯
Kunihiro Matsumoto,

Affiliation Department of Molecular Biology, Graduate School of Science, Institute for Advanced Research, Nagoya Solution-Oriented Research for Science and Technology, Japan Science and Technology Corporation, Chikusa-ku, Nagoya, Japan
⨯
Maria Hatzoglou,

Affiliation Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Hui Jin,

Affiliation Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Zhaoyang Feng

* E-mail: john.feng@case.edu

Affiliations Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Physiology, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China
⨯

Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans

Yiyuan Yuan,
Pengxiu Cao,
Mark A. Smith,
Kristopher Kramp,
Ying Huang,
Naoki Hisamoto,
Kunihiro Matsumoto,
Maria Hatzoglou,
Hui Jin,
Zhaoyang Feng

Published: August 3, 2011
https://doi.org/10.1371/journal.pone.0022354

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