Accelerating Haplotype-Based Genome-Wide Association Study Using Perfect Phylogeny and Phase-Known Reference Data

Yungang He; Cong Li; Christopher I. Amos; Momiao Xiong; Hua Ling; Li Jin

doi:10.1371/journal.pone.0022097

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Peer-reviewed

Research Article

Accelerating Haplotype-Based Genome-Wide Association Study Using Perfect Phylogeny and Phase-Known Reference Data

Yungang He ,

Contributed equally to this work with: Yungang He, Cong Li

* E-mail: heyungang@gmail.com (YH); lijin.fudan@gmail.com (LJ)

Affiliations Department of Computational Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
⨯
Cong Li ,

Contributed equally to this work with: Yungang He, Cong Li

Affiliations Department of Computational Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
⨯
Christopher I. Amos,

Affiliation Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Momiao Xiong,

Affiliations Human Genetics Center, University of Texas School of Public Health, Houston, Texas, United States of America, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
⨯
Hua Ling,

Affiliation Center for Inherited Disease Research, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Li Jin

* E-mail: heyungang@gmail.com (YH); lijin.fudan@gmail.com (LJ)

Affiliations Department of Computational Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
⨯

Accelerating Haplotype-Based Genome-Wide Association Study Using Perfect Phylogeny and Phase-Known Reference Data

Yungang He,
Cong Li,
Christopher I. Amos,
Momiao Xiong,
Hua Ling,
Li Jin

Published: July 15, 2011
https://doi.org/10.1371/journal.pone.0022097

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Haplotypes
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Genome-wide association studies
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Single nucleotide polymorphisms
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Rheumatoid arthritis
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Genotyping
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Variant genotypes
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Algorithms
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