Broad-Spectrum Inhibition of HIV-1 by a Monoclonal Antibody Directed against a gp120-Induced Epitope of CD4

Samuele E. Burastero; Barbara Frigerio; Lucia Lopalco; Francesca Sironi; Daniela Breda; Renato Longhi; Gabriella Scarlatti; Silvana Canevari; Mariangela Figini; Paolo Lusso

doi:10.1371/journal.pone.0022081

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Open Access

Peer-reviewed

Research Article

Broad-Spectrum Inhibition of HIV-1 by a Monoclonal Antibody Directed against a gp120-Induced Epitope of CD4

Samuele E. Burastero ,

* E-mail: s.burastero@hsr.it

Affiliation Department of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
⨯
Barbara Frigerio,

Affiliation Unit of Molecular Therapies, Department of Experimental Oncology and Laboratories Fondazione IRCCS, National Institute of Tumors, Milan, Italy
⨯
Lucia Lopalco,

Affiliation Department of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
⨯
Francesca Sironi,

Affiliation Department of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
⨯
Daniela Breda,

Affiliation Department of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
⨯
Renato Longhi,

Affiliation Institute of Chemistry of Molecular Recognition, National Research Council, Milan, Italy
⨯
Gabriella Scarlatti,

Affiliation Department of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
⨯
Silvana Canevari,

Affiliation Unit of Molecular Therapies, Department of Experimental Oncology and Laboratories Fondazione IRCCS, National Institute of Tumors, Milan, Italy
⨯
Mariangela Figini,

Affiliation Unit of Molecular Therapies, Department of Experimental Oncology and Laboratories Fondazione IRCCS, National Institute of Tumors, Milan, Italy
⨯
Paolo Lusso

Current address: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Affiliation Department of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
⨯

Broad-Spectrum Inhibition of HIV-1 by a Monoclonal Antibody Directed against a gp120-Induced Epitope of CD4

Samuele E. Burastero,
Barbara Frigerio,
Lucia Lopalco,
Francesca Sironi,
Daniela Breda,
Renato Longhi,
Gabriella Scarlatti,
Silvana Canevari,
Mariangela Figini,
Paolo Lusso

Published: July 19, 2011
https://doi.org/10.1371/journal.pone.0022081

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