An Intronic Variant in the GRP78, a Stress-Associated Gene, Improves Prediction for Liver Cirrhosis in Persistent HBV Carriers

Xiao Zhu; Lianzhou Chen; Wenguo Fan; Marie C. M. Lin; Linwei Tian; Min Wang; Sheng Lin; Zifeng Wang; Jinfang Zhang; Jinlong Wang; Hong Yao; Hsiangfu Kung; Dongpei Li

doi:10.1371/journal.pone.0021997

Loading metrics

Open Access

Peer-reviewed

Research Article

An Intronic Variant in the GRP78, a Stress-Associated Gene, Improves Prediction for Liver Cirrhosis in Persistent HBV Carriers

Xiao Zhu ,

Contributed equally to this work with: Xiao Zhu, Lianzhou Chen, Wenguo Fan

* E-mail: bioxzhu@yahoo.com (XZ); lidp@mail.sysu.edu.cn (DL)

Affiliations Cancer Institute, Affiliated Tumor Hospital, Guangzhou Medical University, Guangzhou, China, Key Laboratory of Molecular Diagnosis, Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Dongguan, China
⨯
Lianzhou Chen ,

Contributed equally to this work with: Xiao Zhu, Lianzhou Chen, Wenguo Fan

Affiliation Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
⨯
Wenguo Fan ,

Contributed equally to this work with: Xiao Zhu, Lianzhou Chen, Wenguo Fan

Affiliation Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Marie C. M. Lin,

Affiliation Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
⨯
Linwei Tian,

Affiliation Department of Epidemiology, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China
⨯
Min Wang,

Affiliation Cancer Institute, Affiliated Tumor Hospital, Guangzhou Medical University, Guangzhou, China
⨯
Sheng Lin,

Affiliation Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
⨯
Zifeng Wang,

Affiliation Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
⨯
Jinfang Zhang,

Affiliation Stanley Ho Center for Emerging Infectious Diseases, and Li Ka Shing Institute of Medical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Jinlong Wang,

Affiliation Cancer Institute, Affiliated Tumor Hospital, Guangzhou Medical University, Guangzhou, China
⨯
Hong Yao,

Affiliations Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, Stanley Ho Center for Emerging Infectious Diseases, and Li Ka Shing Institute of Medical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Hsiangfu Kung,

Affiliation Stanley Ho Center for Emerging Infectious Diseases, and Li Ka Shing Institute of Medical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Dongpei Li

* E-mail: bioxzhu@yahoo.com (XZ); lidp@mail.sysu.edu.cn (DL)

Affiliation Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯

An Intronic Variant in the GRP78, a Stress-Associated Gene, Improves Prediction for Liver Cirrhosis in Persistent HBV Carriers

Xiao Zhu,
Lianzhou Chen,
Wenguo Fan,
Marie C. M. Lin,
Linwei Tian,
Min Wang,
Sheng Lin,
Zifeng Wang,
Jinfang Zhang,
Jinlong Wang

Published: July 14, 2011
https://doi.org/10.1371/journal.pone.0021997

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cirrhosis
Is the Subject Area "Cirrhosis" applicable to this article?

Thanks for your feedback.
Hepatitis B virus
Is the Subject Area "Hepatitis B virus" applicable to this article?

Thanks for your feedback.
Variant genotypes
Is the Subject Area "Variant genotypes" applicable to this article?

Thanks for your feedback.
Endoplasmic reticulum
Is the Subject Area "Endoplasmic reticulum" applicable to this article?

Thanks for your feedback.
Hepatitis B
Is the Subject Area "Hepatitis B" applicable to this article?

Thanks for your feedback.
Chronic hepatitis
Is the Subject Area "Chronic hepatitis" applicable to this article?

Thanks for your feedback.
Hepatocellular carcinoma
Is the Subject Area "Hepatocellular carcinoma" applicable to this article?

Thanks for your feedback.
Liver diseases
Is the Subject Area "Liver diseases" applicable to this article?

Thanks for your feedback.