Bacteria-Specific Neutrophil Dysfunction Associated with Interferon-Stimulated Gene Expression in the Acute Respiratory Distress Syndrome

Kenneth C. Malcolm; Jennifer E. Kret; Robert L. Young; Katie R. Poch; Silvia M. Caceres; Ivor S. Douglas; Chris D. Coldren; Ellen L. Burnham; Marc Moss; Jerry A. Nick

doi:10.1371/journal.pone.0021958

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Open Access

Peer-reviewed

Research Article

Bacteria-Specific Neutrophil Dysfunction Associated with Interferon-Stimulated Gene Expression in the Acute Respiratory Distress Syndrome

Kenneth C. Malcolm ,

* E-mail: malcolmk@njhealth.org

Affiliations Department of Medicine, National Jewish Health, Denver, Colorado, United States of America, Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America
⨯
Jennifer E. Kret,

Affiliation Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
⨯
Robert L. Young,

Affiliations Department of Medicine, National Jewish Health, Denver, Colorado, United States of America, Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America
⨯
Katie R. Poch,

Affiliation Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
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Silvia M. Caceres,

Affiliation Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
⨯
Ivor S. Douglas,

Affiliations Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America, Pulmonary and Critical Care, Department of Medicine, Denver Health Medical Center, Denver, Colorado, United States of America
⨯
Chris D. Coldren,

Affiliation Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America
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Ellen L. Burnham,

Affiliation Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America
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Marc Moss,

Affiliation Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America
⨯
Jerry A. Nick

Affiliations Department of Medicine, National Jewish Health, Denver, Colorado, United States of America, Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America
⨯

Bacteria-Specific Neutrophil Dysfunction Associated with Interferon-Stimulated Gene Expression in the Acute Respiratory Distress Syndrome

Kenneth C. Malcolm,
Jennifer E. Kret,
Robert L. Young,
Katie R. Poch,
Silvia M. Caceres,
Ivor S. Douglas,
Chris D. Coldren,
Ellen L. Burnham,
Marc Moss,
Jerry A. Nick

Published: July 6, 2011
https://doi.org/10.1371/journal.pone.0021958

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Neutrophils
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Apoptosis
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Staphylococcus aureus
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Pseudomonas aeruginosa
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Acute respiratory distress syndrome
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Necrotic cell death
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Viral transmission and infection
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