NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease

Anthony L. Cook; Alejandra M. Vitale; Sugandha Ravishankar; Nicholas Matigian; Greg T. Sutherland; Jiangou Shan; Ratneswary Sutharsan; Chris Perry; Peter A. Silburn; George D. Mellick; Murray L. Whitelaw; Christine A. Wells; Alan Mackay-Sim; Stephen A. Wood

doi:10.1371/journal.pone.0021907

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Peer-reviewed

Research Article

NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease

Anthony L. Cook,

Current address: School of Human Life Sciences, University of Tasmania, Tasmania, Australia

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯
Alejandra M. Vitale,

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯
Sugandha Ravishankar,

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯
Nicholas Matigian,

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯
Greg T. Sutherland,

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯
Jiangou Shan,

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯
Ratneswary Sutharsan,

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯
Chris Perry,

Affiliations National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia, Department of Otolaryngology Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia
⨯
Peter A. Silburn,

Affiliations National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
⨯
George D. Mellick,

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯
Murray L. Whitelaw,

Affiliation School of Molecular and Biomedical Science (Biochemistry), University of Adelaide, Adelaide, South Australia, Australia
⨯
Christine A. Wells,

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯
Alan Mackay-Sim,

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯
Stephen A. Wood

* E-mail: s.wood@griffith.edu.au

Affiliation National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
⨯

NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease

Anthony L. Cook,
Alejandra M. Vitale,
Sugandha Ravishankar,
Nicholas Matigian,
Greg T. Sutherland,
Jiangou Shan,
Ratneswary Sutharsan,
Chris Perry,
Peter A. Silburn,
George D. Mellick

Published: July 1, 2011
https://doi.org/10.1371/journal.pone.0021907

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