Hypertension Is Associated with Marked Alterations in Sphingolipid Biology: A Potential Role for Ceramide

Léon J. A. Spijkers; Rob F. P. van den Akker; Ben J. A. Janssen; Jacques J. Debets; Jo G. R. De Mey; Erik S. G. Stroes; Bert-Jan H. van den Born; Dayanjan S. Wijesinghe; Charles E. Chalfant; Luke MacAleese; Gert B. Eijkel; Ron M. A. Heeren; Astrid E. Alewijnse; Stephan L. M. Peters

doi:10.1371/journal.pone.0021817

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Open Access

Peer-reviewed

Research Article

Hypertension Is Associated with Marked Alterations in Sphingolipid Biology: A Potential Role for Ceramide

Léon J. A. Spijkers,

Affiliation Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands
⨯
Rob F. P. van den Akker,

Affiliation Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands
⨯
Ben J. A. Janssen,

Affiliation Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands
⨯
Jacques J. Debets,

Affiliation Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands
⨯
Jo G. R. De Mey,

Affiliation Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands
⨯
Erik S. G. Stroes,

Affiliation Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
⨯
Bert-Jan H. van den Born,

Affiliation Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
⨯
Dayanjan S. Wijesinghe,

Affiliation Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Charles E. Chalfant,

Affiliation Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Luke MacAleese,

Affiliation FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
⨯
Gert B. Eijkel,

Affiliation FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
⨯
Ron M. A. Heeren,

Affiliation FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
⨯
Astrid E. Alewijnse,

Affiliation Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands
⨯
Stephan L. M. Peters

* E-mail: s.l.peters@amc.uva.nl

Affiliation Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands
⨯

Hypertension Is Associated with Marked Alterations in Sphingolipid Biology: A Potential Role for Ceramide

Léon J. A. Spijkers,
Rob F. P. van den Akker,
Ben J. A. Janssen,
Jacques J. Debets,
Jo G. R. De Mey,
Erik S. G. Stroes,
Bert-Jan H. van den Born,
Dayanjan S. Wijesinghe,
Charles E. Chalfant,
Luke MacAleese

Published: July 19, 2011
https://doi.org/10.1371/journal.pone.0021817

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