VapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins

• Bintou Ahmadou Ahidjo,

  Affiliation Medical Research Council, National Health Laboratory Service, University of the Witwatersrand Molecular Mycobacteriology Research Unit, Department of Science and Technology, National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa

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• Diane Kuhnert,

  Affiliation Medical Research Council, National Health Laboratory Service, University of the Witwatersrand Molecular Mycobacteriology Research Unit, Department of Science and Technology, National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa

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• Joanna L. McKenzie,

  Affiliation Department of Biological Sciences, University of Waikato, Hamilton, New Zealand

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• Edith E. Machowski,

  Affiliation Medical Research Council, National Health Laboratory Service, University of the Witwatersrand Molecular Mycobacteriology Research Unit, Department of Science and Technology, National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa

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• Bhavna G. Gordhan,

  Affiliation Medical Research Council, National Health Laboratory Service, University of the Witwatersrand Molecular Mycobacteriology Research Unit, Department of Science and Technology, National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa

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• Vickery Arcus,

  Affiliation Department of Biological Sciences, University of Waikato, Hamilton, New Zealand

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• Garth L. Abrahams,

  Current address: Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

  Affiliation Medical Research Council, National Health Laboratory Service, University of the Witwatersrand Molecular Mycobacteriology Research Unit, Department of Science and Technology, National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa

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• Valerie Mizrahi

  * E-mail: valerie.mizrahi@uct.ac.za

  Current address: Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

  Affiliation Medical Research Council, National Health Laboratory Service, University of the Witwatersrand Molecular Mycobacteriology Research Unit, Department of Science and Technology, National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa

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