Amitriptyline-Mediated Cognitive Enhancement in Aged 3×Tg Alzheimer's Disease Mice Is Associated with Neurogenesis and Neurotrophic Activity

Wayne Chadwick; Nick Mitchell; Jenna Caroll; Yu Zhou; Sung-Soo Park; Liyun Wang; Kevin G. Becker; Yongqing Zhang; Elin Lehrmann; William H. Wood III; Bronwen Martin; Stuart Maudsley

doi:10.1371/journal.pone.0021660

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Peer-reviewed

Research Article

Amitriptyline-Mediated Cognitive Enhancement in Aged 3×Tg Alzheimer's Disease Mice Is Associated with Neurogenesis and Neurotrophic Activity

Wayne Chadwick,

Affiliation Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Nick Mitchell,

Affiliation Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Jenna Caroll,

Affiliation Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Yu Zhou,

Affiliation Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Sung-Soo Park,

Affiliation Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Liyun Wang,

Affiliation Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Kevin G. Becker,

Affiliation Genomics Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Yongqing Zhang,

Affiliation Genomics Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Elin Lehrmann,

Affiliation Genomics Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
William H. Wood III,

Affiliation Genomics Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Bronwen Martin,

Affiliation Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Stuart Maudsley

* E-mail: maudsleyst@mail.nih.gov

Affiliation Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯

Amitriptyline-Mediated Cognitive Enhancement in Aged 3×Tg Alzheimer's Disease Mice Is Associated with Neurogenesis and Neurotrophic Activity

Wayne Chadwick,
Nick Mitchell,
Jenna Caroll,
Yu Zhou,
Sung-Soo Park,
Liyun Wang,
Kevin G. Becker,
Yongqing Zhang,
Elin Lehrmann,
William H. Wood III

Published: June 27, 2011
https://doi.org/10.1371/journal.pone.0021660

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