TMPRSS2/ERG Promotes Epithelial to Mesenchymal Transition through the ZEB1/ZEB2 Axis in a Prostate Cancer Model

Orit Leshem; Shalom Madar; Ira Kogan-Sakin; Iris Kamer; Ido Goldstein; Ran Brosh; Yehudit Cohen; Jasmine Jacob-Hirsch; Marcelo Ehrlich; Shmuel Ben-Sasson; Naomi Goldfinger; Ron Loewenthal; Ephraim Gazit; Varda Rotter; Raanan Berger

doi:10.1371/journal.pone.0021650

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Open Access

Peer-reviewed

Research Article

TMPRSS2/ERG Promotes Epithelial to Mesenchymal Transition through the ZEB1/ZEB2 Axis in a Prostate Cancer Model

Orit Leshem ,

Contributed equally to this work with: Orit Leshem, Shalom Madar

Affiliations Sheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel, Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Shalom Madar ,

Contributed equally to this work with: Orit Leshem, Shalom Madar

Affiliation Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
⨯
Ira Kogan-Sakin,

Affiliation Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
⨯
Iris Kamer,

Affiliation Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
⨯
Ido Goldstein,

Affiliation Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
⨯
Ran Brosh,

Affiliation Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
⨯
Yehudit Cohen,

Affiliation Sheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
⨯
Jasmine Jacob-Hirsch,

Affiliation Sheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
⨯
Marcelo Ehrlich,

Affiliation Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
⨯
Shmuel Ben-Sasson,

Affiliation Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Naomi Goldfinger,

Affiliation Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
⨯
Ron Loewenthal,

Affiliation Tissue Typing Unit, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
⨯
Ephraim Gazit,

Affiliation Tissue Typing Unit, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
⨯
Varda Rotter,

Affiliation Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
⨯
Raanan Berger

* E-mail: raanan.berger@sheba.health.gov.il

Affiliation Sheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
⨯

TMPRSS2/ERG Promotes Epithelial to Mesenchymal Transition through the ZEB1/ZEB2 Axis in a Prostate Cancer Model

Orit Leshem,
Shalom Madar,
Ira Kogan-Sakin,
Iris Kamer,
Ido Goldstein,
Ran Brosh,
Yehudit Cohen,
Jasmine Jacob-Hirsch,
Marcelo Ehrlich,
Shmuel Ben-Sasson

Published: July 1, 2011
https://doi.org/10.1371/journal.pone.0021650

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