Endoplasmic Reticulum Stress-Induced JNK Activation Is a Critical Event Leading to Mitochondria-Mediated Cell Death Caused by β-Lapachone Treatment

Hyemi Lee; Moon-Taek Park; Bo-Hwa Choi; Eun-Taex Oh; Min-Jeong Song; Jeonghun Lee; Chulhee Kim; Byung Uk Lim; Heon Joo Park

doi:10.1371/journal.pone.0021533

Loading metrics

Open Access

Peer-reviewed

Research Article

Endoplasmic Reticulum Stress-Induced JNK Activation Is a Critical Event Leading to Mitochondria-Mediated Cell Death Caused by β-Lapachone Treatment

Hyemi Lee ,

Contributed equally to this work with: Hyemi Lee, Moon-Taek Park

Affiliation Department of Microbiology, College of Medicine, Center for Advanced Medical Education by BK21 Project, Inha University, Incheon, Republic of Korea
⨯
Moon-Taek Park ,

Contributed equally to this work with: Hyemi Lee, Moon-Taek Park

Affiliation Department of Microbiology, College of Medicine, Center for Advanced Medical Education by BK21 Project, Inha University, Incheon, Republic of Korea
⨯
Bo-Hwa Choi,

Affiliation Department of Microbiology, College of Medicine, Center for Advanced Medical Education by BK21 Project, Inha University, Incheon, Republic of Korea
⨯
Eun-Taex Oh,

Affiliation Department of Microbiology, College of Medicine, Center for Advanced Medical Education by BK21 Project, Inha University, Incheon, Republic of Korea
⨯
Min-Jeong Song,

Affiliation Department of Microbiology, College of Medicine, Center for Advanced Medical Education by BK21 Project, Inha University, Incheon, Republic of Korea
⨯
Jeonghun Lee,

Affiliation Department of Polymer Science and Engineering, Inha University, Incheon, Korea
⨯
Chulhee Kim,

Affiliation Department of Polymer Science and Engineering, Inha University, Incheon, Korea
⨯
Byung Uk Lim,

Affiliation Department of Microbiology, College of Medicine, Center for Advanced Medical Education by BK21 Project, Inha University, Incheon, Republic of Korea
⨯
Heon Joo Park

* E-mail: park001@inha.ac.kr

Affiliation Department of Microbiology, College of Medicine, Center for Advanced Medical Education by BK21 Project, Inha University, Incheon, Republic of Korea
⨯

Endoplasmic Reticulum Stress-Induced JNK Activation Is a Critical Event Leading to Mitochondria-Mediated Cell Death Caused by β-Lapachone Treatment

Hyemi Lee,
Moon-Taek Park,
Bo-Hwa Choi,
Eun-Taex Oh,
Min-Jeong Song,
Jeonghun Lee,
Chulhee Kim,
Byung Uk Lim,
Heon Joo Park

Published: June 29, 2011
https://doi.org/10.1371/journal.pone.0021533

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Membrane potential
Is the Subject Area "Membrane potential" applicable to this article?

Thanks for your feedback.
Mitochondrial membrane
Is the Subject Area "Mitochondrial membrane" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.