Schwann-Spheres Derived from Injured Peripheral Nerves in Adult Mice - Their In Vitro Characterization and Therapeutic Potential

Takehiko Takagi; Ken Ishii; Shinsuke Shibata; Akimasa Yasuda; Momoka Sato; Narihito Nagoshi; Harukazu Saito; Hirotaka J. Okano; Yoshiaki Toyama; Hideyuki Okano; Masaya Nakamura

doi:10.1371/journal.pone.0021497

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Open Access

Peer-reviewed

Research Article

Schwann-Spheres Derived from Injured Peripheral Nerves in Adult Mice - Their In Vitro Characterization and Therapeutic Potential

Takehiko Takagi,

Affiliations Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, Department of Physiology, Keio University School of Medicine, Tokyo, Japan
⨯
Ken Ishii,

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
⨯
Shinsuke Shibata,

Affiliation Department of Physiology, Keio University School of Medicine, Tokyo, Japan
⨯
Akimasa Yasuda,

Affiliations Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, Department of Physiology, Keio University School of Medicine, Tokyo, Japan
⨯
Momoka Sato,

Affiliations Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, Department of Physiology, Keio University School of Medicine, Tokyo, Japan, Center for Integrated Medical Research, Keio University, Tokyo, Japan
⨯
Narihito Nagoshi,

Affiliation Department of Orthopaedic Surgery, Murayama Medical Center, National Hospital Organization, Tokyo, Japan
⨯
Harukazu Saito,

Affiliation Department of Orthopaedic Surgery, Murayama Medical Center, National Hospital Organization, Tokyo, Japan
⨯
Hirotaka J. Okano,

Affiliation Department of Physiology, Keio University School of Medicine, Tokyo, Japan
⨯
Yoshiaki Toyama,

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
⨯
Hideyuki Okano ,

* E-mail: masa@sc.itc.keio.ac.jp (MN); hidokano@sc.itc.keio.ac.jp (HO)

Affiliation Department of Physiology, Keio University School of Medicine, Tokyo, Japan
⨯
Masaya Nakamura

* E-mail: masa@sc.itc.keio.ac.jp (MN); hidokano@sc.itc.keio.ac.jp (HO)

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
⨯

Schwann-Spheres Derived from Injured Peripheral Nerves in Adult Mice - Their In Vitro Characterization and Therapeutic Potential

Takehiko Takagi,
Ken Ishii,
Shinsuke Shibata,
Akimasa Yasuda,
Momoka Sato,
Narihito Nagoshi,
Harukazu Saito,
Hirotaka J. Okano,
Yoshiaki Toyama,
Hideyuki Okano

Published: June 24, 2011
https://doi.org/10.1371/journal.pone.0021497

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Sciatic nerves
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Schwann cells
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Nerves
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Cell differentiation
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