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Open Access
Peer-reviewed
Research Article
AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo
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Hua Xie ,
Contributed equally to this work with: Hua Xie, Liping Lin
Affiliation State Key Laboratory of Drug Research, Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Liping Lin ,
Contributed equally to this work with: Hua Xie, Liping Lin
Affiliation State Key Laboratory of Drug Research, Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Linjiang Tong,
Affiliation State Key Laboratory of Drug Research, Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Yong Jiang,
Affiliation Shanghai Allist Pharmaceuticals, Shanghai, China
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Mingyue Zheng,
Affiliation State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Zhuo Chen,
Affiliation State Key Laboratory of Drug Research, Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Xiaoyan Jiang,
Affiliation Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Xiaowei Zhang,
Affiliation State Key Laboratory of Drug Research, Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Xiaowei Ren,
Affiliation Shanghai Allist Pharmaceuticals, Shanghai, China
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Wenchao Qu,
Affiliation Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Yang Yang,
Affiliation Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Hua Wan,
Affiliation Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Yi Chen,
Affiliation State Key Laboratory of Drug Research, Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Jianping Zuo,
Affiliation Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Hualiang Jiang,
Affiliation State Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Meiyu Geng,
Affiliation State Key Laboratory of Drug Research, Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Jian Ding
* E-mail: suozhang@mail.shcnc.ac.cn
Affiliation State Key Laboratory of Drug Research, Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo
- Hua Xie,
- Liping Lin,
- Linjiang Tong,
- Yong Jiang,
- Mingyue Zheng,
- Zhuo Chen,
- Xiaoyan Jiang,
- Xiaowei Zhang,
- Xiaowei Ren,
- Wenchao Qu
- Published: July 18, 2011
- https://doi.org/10.1371/journal.pone.0021487