Endothelial Cell-Specific Molecule 2 (ECSM2) Localizes to Cell-Cell Junctions and Modulates bFGF-Directed Cell Migration via the ERK-FAK Pathway

Chunwei Shi; Jia Lu; Wen Wu; Fanxin Ma; Joseph Georges; Hanju Huang; James Balducci; Yongchang Chang; Yao Huang

doi:10.1371/journal.pone.0021482

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Research Article

Endothelial Cell-Specific Molecule 2 (ECSM2) Localizes to Cell-Cell Junctions and Modulates bFGF-Directed Cell Migration via the ERK-FAK Pathway

Chunwei Shi,

Affiliations Department of Obstetrics and Gynecology, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America, Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Jia Lu,

Affiliations Department of Obstetrics and Gynecology, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America, Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Wen Wu,

Affiliations Department of Obstetrics and Gynecology, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America, Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Fanxin Ma,

Affiliations Department of Obstetrics and Gynecology, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America, State Key Laboratory of Biotherapy, West China Hospital, College of Life Science, Sichuan University, Chengdu, China
⨯
Joseph Georges,

Affiliation Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America
⨯
Hanju Huang,

Affiliation Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
James Balducci,

Affiliation Department of Obstetrics and Gynecology, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America
⨯
Yongchang Chang,

Affiliation Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America
⨯
Yao Huang

* E-mail: yhuang@chw.edu

Affiliation Department of Obstetrics and Gynecology, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States of America
⨯

Endothelial Cell-Specific Molecule 2 (ECSM2) Localizes to Cell-Cell Junctions and Modulates bFGF-Directed Cell Migration via the ERK-FAK Pathway

Chunwei Shi,
Jia Lu,
Wen Wu,
Fanxin Ma,
Joseph Georges,
Hanju Huang,
James Balducci,
Yongchang Chang,
Yao Huang

Published: June 24, 2011
https://doi.org/10.1371/journal.pone.0021482

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Cell migration
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Immunoblotting
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ERK signaling cascade
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