Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression

• Gerard ILL-Raga,

  Affiliation Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain

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• Ernest Palomer,

  Affiliation Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain

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• Matthew A. Wozniak,

  Affiliation University of Manchester, Manchester, United Kingdom

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• Eva Ramos-Fernández,

  Affiliation Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain

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• Mònica Bosch-Morató,

  Affiliation Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain

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• Marta Tajes,

  Affiliation Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain

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• Francesc X. Guix,

  Affiliation Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain

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• José J. Galán,

  Affiliation NeoCodex, Sevilla, Spain

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• Jordi Clarimón,

  Affiliation Alzheimer Laboratory, Neurology Department, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain

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• Carmen Antúnez,

  Affiliation Fundación Alzheimur, Unidad de Demencias, Hospital Virgen de la Arrixaca de Murcia, Murcia, Spain

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• Luis M. Real,

  Affiliation NeoCodex, Sevilla, Spain

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• Mercé Boada,

  Affiliations Memory Clinic of ACE Foundation, Catalan Institute of Applied Neurosciences, Barcelona, Spain, Neurology Department, Hospital G. Universitari Vall d'Hebron, Barcelona, Spain

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• Ruth F. Itzhaki,

  Affiliation University of Manchester, Manchester, United Kingdom

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• César Fandos,

  Affiliation Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain

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• Francisco J. Muñoz

  * E-mail: paco.munoz@upf.edu

  Affiliation Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain

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