Resistance of a Rodent Malaria Parasite to a Thymidylate Synthase Inhibitor Induces an Apoptotic Parasite Death and Imposes a Huge Cost of Fitness

• Francis W. Muregi ,

  * E-mail: fmuregi@kemri.org

  Affiliations Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu, Japan, Centre for Biotechnology Research and Development, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya

  ⨯
• Isao Ohta,

  Affiliation Laboratory for Ultrastructure Research, Research Equipment Centre, Hamamatsu University School of Medicine, Hamamatsu, Japan

  ⨯
• Uchijima Masato,

  Affiliation Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu, Japan

  ⨯
• Hideto Kino,

  Affiliation Institute of Experimental Animals, Hamamatsu University School of Medicine, Hamamatsu, Japan

  ⨯
• Akira Ishih

  Affiliation Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu, Japan

  ⨯