Amino Acid Substitutions at the Major Insertion Loop of Candida albicans Sterol 14alpha-Demethylase Are Involved in Fluconazole Resistance

Nidia Alvarez-Rueda; Audrey Fleury; Florent Morio; Fabrice Pagniez; Louis Gastinel; Patrice Le Pape

doi:10.1371/journal.pone.0021239

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Peer-reviewed

Research Article

Amino Acid Substitutions at the Major Insertion Loop of Candida albicans Sterol 14alpha-Demethylase Are Involved in Fluconazole Resistance

Nidia Alvarez-Rueda ,

* E-mail: patrice.le-pape@univ-nantes.fr (PLP); nidia.alvarez-rueda@univ-nantes.fr (NAR)

Affiliation Département de Parasitologie et de Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155 – IICiMed, Faculté de Pharmacie de Nantes, Nantes, France
⨯
Audrey Fleury,

Affiliation Département de Parasitologie et de Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155 – IICiMed, Faculté de Pharmacie de Nantes, Nantes, France
⨯
Florent Morio,

Affiliations Département de Parasitologie et de Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155 – IICiMed, Faculté de Pharmacie de Nantes, Nantes, France, Laboratoire de Parasitologie-Mycologie, CHU de Nantes, Nantes, France
⨯
Fabrice Pagniez,

Affiliation Département de Parasitologie et de Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155 – IICiMed, Faculté de Pharmacie de Nantes, Nantes, France
⨯
Louis Gastinel,

Affiliation Laboratoire de Pharmacologie des Immunosuppresseurs en Transplantation, INSERM UMR 850, Université de Limoges, Limoges, France
⨯
Patrice Le Pape

* E-mail: patrice.le-pape@univ-nantes.fr (PLP); nidia.alvarez-rueda@univ-nantes.fr (NAR)

Affiliations Département de Parasitologie et de Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155 – IICiMed, Faculté de Pharmacie de Nantes, Nantes, France, Laboratoire de Parasitologie-Mycologie, CHU de Nantes, Nantes, France
⨯

Amino Acid Substitutions at the Major Insertion Loop of Candida albicans Sterol 14alpha-Demethylase Are Involved in Fluconazole Resistance

Nidia Alvarez-Rueda,
Audrey Fleury,
Florent Morio,
Fabrice Pagniez,
Louis Gastinel,
Patrice Le Pape

Published: June 16, 2011
https://doi.org/10.1371/journal.pone.0021239

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Azoles
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Candida albicans
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Amino acid substitution
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