Physical Exercise Regulates p53 Activity Targeting SCO2 and Increases Mitochondrial COX Biogenesis in Cardiac Muscle with Age

Zhengtang Qi; Jie He; Yuhui Su; Qiang He; Jingxia Liu; Lu Yu; Omar Al-Attas; Tajamul Hussain; Shuzhe Ding; Liu Ji; Min Qian

doi:10.1371/journal.pone.0021140

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Peer-reviewed

Research Article

Physical Exercise Regulates p53 Activity Targeting SCO2 and Increases Mitochondrial COX Biogenesis in Cardiac Muscle with Age

Zhengtang Qi,

Affiliations Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, Shanghai, China, College of Physical Education and Health, East China Normal University, Shanghai, China, Institute of Biomedical Sciences, East China Normal University, Shanghai, China
⨯
Jie He,

Affiliation Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, Shanghai, China
⨯
Yuhui Su,

Affiliation Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, Shanghai, China
⨯
Qiang He,

Affiliation Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, Shanghai, China
⨯
Jingxia Liu,

Affiliation Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, Shanghai, China
⨯
Lu Yu,

Affiliation Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, Shanghai, China
⨯
Omar Al-Attas,

Affiliation Center of Excellence in Biotechnology Research, King Saud University, Riyadh, Saudi Arabia
⨯
Tajamul Hussain,

Affiliation Center of Excellence in Biotechnology Research, King Saud University, Riyadh, Saudi Arabia
⨯
Shuzhe Ding ,

* E-mail: szding@tyxx.ecnu.edu.cn

Affiliations Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, Shanghai, China, College of Physical Education and Health, East China Normal University, Shanghai, China
⨯
Liu Ji,

Affiliations Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, Shanghai, China, College of Physical Education and Health, East China Normal University, Shanghai, China
⨯
Min Qian

Affiliation Institute of Biomedical Sciences, East China Normal University, Shanghai, China
⨯

Physical Exercise Regulates p53 Activity Targeting SCO2 and Increases Mitochondrial COX Biogenesis in Cardiac Muscle with Age

Zhengtang Qi,
Jie He,
Yuhui Su,
Qiang He,
Jingxia Liu,
Lu Yu,
Omar Al-Attas,
Tajamul Hussain,
Shuzhe Ding,
Liu Ji

Published: July 7, 2011
https://doi.org/10.1371/journal.pone.0021140

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Mitochondria
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Exercise
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Cardiac muscles
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Oxidative stress
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