Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2α Accumulation and Promotes Migration and Invasion

Sunil Sudarshan; Karthigayan Shanmugasundaram; Susan L. Naylor; Shu Lin; Carolina B. Livi; Christine F. O'Neill; Dipen J. Parekh; I-Tien Yeh; Lu-Zhe Sun; Karen Block

doi:10.1371/journal.pone.0021037

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Peer-reviewed

Research Article

Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2α Accumulation and Promotes Migration and Invasion

Sunil Sudarshan ,

* E-mail: sudarshan@uthscsa.edu

Affiliations Department of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
Karthigayan Shanmugasundaram,

Affiliations Department of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
Susan L. Naylor,

Affiliations Department of Cellular and Structural Biology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
Shu Lin,

Affiliations Department of Cellular and Structural Biology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
Carolina B. Livi,

Affiliations Department of Molecular Medicine, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Department of Epidemiology and Biostatistics, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
Christine F. O'Neill,

Affiliations Department of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
Dipen J. Parekh,

Affiliations Department of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
I-Tien Yeh,

Affiliations Department of Pathology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
Lu-Zhe Sun,

Affiliations Department of Cellular and Structural Biology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
Karen Block

Affiliations Department of Medicine, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, United States of America, Audie L. Murphy Memorial Hospital Division, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯

Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2α Accumulation and Promotes Migration and Invasion

Sunil Sudarshan,
Karthigayan Shanmugasundaram,
Susan L. Naylor,
Shu Lin,
Carolina B. Livi,
Christine F. O'Neill,
Dipen J. Parekh,
I-Tien Yeh,
Lu-Zhe Sun,
Karen Block

Published: June 14, 2011
https://doi.org/10.1371/journal.pone.0021037

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15 Jul 2011
15:04 GMT
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Media Coverage of This Article Posted by PLOS_ONE_Group on 15 Jul 2011 at 15:04 GMT
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05 Jul 2011
22:53 GMT
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Publisher's Note: Error in affiliations Posted by PLOS_ONE_Group on 05 Jul 2011 at 22:53 GMT

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Renal cancer
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Transfection
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Protein expression
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Immunoblotting
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