Conformational Changes of rBTI from Buckwheat upon Binding to Trypsin: Implications for the Role of the P8′ Residue in the Potato Inhibitor I Family

Longfei Wang; Fei Zhao; Mei Li; Hongmei Zhang; Yu Gao; Peng Cao; Xiaowei Pan; Zhuanhua Wang; Wenrui Chang

doi:10.1371/journal.pone.0020950

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Research Article

Conformational Changes of rBTI from Buckwheat upon Binding to Trypsin: Implications for the Role of the P₈′ Residue in the Potato Inhibitor I Family

Longfei Wang,

Affiliations National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China, Graduate University of the Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Fei Zhao,

Affiliation Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, People's Republic of China
⨯
Mei Li,

Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Hongmei Zhang,

Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Yu Gao,

Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Peng Cao,

Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Xiaowei Pan,

Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯
Zhuanhua Wang ,

* E-mail: wrchang@sun5.ibp.ac.cn (WC); zhwang@sxu.edu.cn (ZW)

Affiliation Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, People's Republic of China
⨯
Wenrui Chang

* E-mail: wrchang@sun5.ibp.ac.cn (WC); zhwang@sxu.edu.cn (ZW)

Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China
⨯

Conformational Changes of rBTI from Buckwheat upon Binding to Trypsin: Implications for the Role of the P₈′ Residue in the Potato Inhibitor I Family

Longfei Wang,
Fei Zhao,
Mei Li,
Hongmei Zhang,
Yu Gao,
Peng Cao,
Xiaowei Pan,
Zhuanhua Wang,
Wenrui Chang

Published: June 15, 2011
https://doi.org/10.1371/journal.pone.0020950

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Serine proteases
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Chemical dissociation
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Hydrogen bonding
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Proteases
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Buckwheat
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Trypsin inhibitors
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Molecular structure
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