A Directed Molecular Evolution Approach to Improved Immunogenicity of the HIV-1 Envelope Glycoprotein

Sean X. Du; Li Xu; Wenge Zhang; Susan Tang; Rebecca I. Boenig; Helen Chen; Ellaine B. Mariano; Michael B. Zwick; Paul W. H. I. Parren; Dennis R. Burton; Terri Wrin; Christos J. Petropoulos; John A. Ballantyne; Michael Chambers; Robert G. Whalen

doi:10.1371/journal.pone.0020927

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Open Access

Peer-reviewed

Research Article

A Directed Molecular Evolution Approach to Improved Immunogenicity of the HIV-1 Envelope Glycoprotein

Sean X. Du,

Current address: Simcere Pharmaceutical Group, Nanjing, People's Republic of China

Affiliation Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America
⨯
Li Xu,

Current address: Sea Lane Biotechnologies LLC, Menlo Park, California, United States of America

Affiliation Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America
⨯
Wenge Zhang,

Affiliation Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America
⨯
Susan Tang,

Affiliation Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America
⨯
Rebecca I. Boenig,

Current address: Altravax, Inc., Sunnyvale, California, United States of America

Affiliation Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America
⨯
Helen Chen,

Affiliation Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America
⨯
Ellaine B. Mariano,

Current address: Altravax, Inc., Sunnyvale, California, United States of America

Affiliation Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America
⨯
Michael B. Zwick,

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Paul W. H. I. Parren,

Current address: Genmab, CM Utrecht, The Netherlands

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Dennis R. Burton,

Affiliations Department of Immunology and Microbial Science, and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Boston, Massachusetts, United States of America
⨯
Terri Wrin,

Affiliation Monogram Biosciences, San Francisco, California, United States of America
⨯
Christos J. Petropoulos,

Affiliation Monogram Biosciences, San Francisco, California, United States of America
⨯
John A. Ballantyne,

Affiliation Aldevron LLC, Fargo, North Dakota, United States of America
⨯
Michael Chambers,

Affiliation Aldevron LLC, Fargo, North Dakota, United States of America
⨯
Robert G. Whalen

* E-mail: robert.whalen@altravax.com

Current address: Altravax, Inc., Sunnyvale, California, United States of America

Affiliation Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America
⨯

A Directed Molecular Evolution Approach to Improved Immunogenicity of the HIV-1 Envelope Glycoprotein

Sean X. Du,
Li Xu,
Wenge Zhang,
Susan Tang,
Rebecca I. Boenig,
Helen Chen,
Ellaine B. Mariano,
Michael B. Zwick,
Paul W. H. I. Parren,
Dennis R. Burton

Published: June 29, 2011
https://doi.org/10.1371/journal.pone.0020927

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