RyRCa2+ Leak Limits Cardiac Ca2+ Window Current Overcoming the Tonic Effect of Calmodulin in Mice

María Fernández-Velasco; Gema Ruiz-Hurtado; Angélica Rueda; Patricia Neco; Martha Mercado-Morales; Carmen Delgado; Carlo Napolitano; Silvia G. Priori; Sylvain Richard; Ana María Gómez; Jean-Pierre Benitah

doi:10.1371/journal.pone.0020863

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Peer-reviewed

Research Article

RyRCa²⁺ Leak Limits Cardiac Ca²⁺ Window Current Overcoming the Tonic Effect of Calmodulin in Mice

María Fernández-Velasco,

Affiliations Inserm, U637, Université Montpellier-1, Université Montpellier-2, Montpellier, France, Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Madrid, Spain
⨯
Gema Ruiz-Hurtado ,

Contributed equally to this work with: Gema Ruiz-Hurtado, Angélica Rueda

Affiliations Inserm, U637, Université Montpellier-1, Université Montpellier-2, Montpellier, France, Inserm, U769, IFR141, Faculté de Pharmacie, Université Paris-Sud 11, Chatenay-Malabry, France
⨯
Angélica Rueda ,

Contributed equally to this work with: Gema Ruiz-Hurtado, Angélica Rueda

Affiliations Inserm, U637, Université Montpellier-1, Université Montpellier-2, Montpellier, France, Department of Biochemistry, CINVESTAV, Mexico City, Mexico
⨯
Patricia Neco,

Affiliations Inserm, U637, Université Montpellier-1, Université Montpellier-2, Montpellier, France, Inserm, U769, IFR141, Faculté de Pharmacie, Université Paris-Sud 11, Chatenay-Malabry, France
⨯
Martha Mercado-Morales,

Affiliation Department of Biochemistry, CINVESTAV, Mexico City, Mexico
⨯
Carmen Delgado,

Affiliation Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, CyB, CSIC, Madrid, Spain
⨯
Carlo Napolitano,

Affiliations Molecular Cardiology, Fondazione Salvatore Maugeri, Pavia, Italy, Cardiovascular Genetics, Leon Charney Division of Cardiology, Langone Medical Center, New York University School of Medicine, New York, United States of America
⨯
Silvia G. Priori,

Affiliations Molecular Cardiology, Fondazione Salvatore Maugeri, Pavia, Italy, Cardiovascular Genetics, Leon Charney Division of Cardiology, Langone Medical Center, New York University School of Medicine, New York, United States of America, Department of Cardiology, University of Pavia, Italy
⨯
Sylvain Richard,

Affiliations Inserm, U637, Université Montpellier-1, Université Montpellier-2, Montpellier, France, Inserm, U1046, Université Montpellier-1, Université Montpellier-2, Montpellier, France
⨯
Ana María Gómez,

Affiliations Inserm, U637, Université Montpellier-1, Université Montpellier-2, Montpellier, France, Inserm, U769, IFR141, Faculté de Pharmacie, Université Paris-Sud 11, Chatenay-Malabry, France
⨯
Jean-Pierre Benitah

* E-mail: jean-pierre.benitah@inserm.fr

Affiliations Inserm, U637, Université Montpellier-1, Université Montpellier-2, Montpellier, France, Inserm, U769, IFR141, Faculté de Pharmacie, Université Paris-Sud 11, Chatenay-Malabry, France
⨯

RyRCa²⁺ Leak Limits Cardiac Ca²⁺ Window Current Overcoming the Tonic Effect of Calmodulin in Mice

María Fernández-Velasco,
Gema Ruiz-Hurtado,
Angélica Rueda,
Patricia Neco,
Martha Mercado-Morales,
Carmen Delgado,
Carlo Napolitano,
Silvia G. Priori,
Sylvain Richard,
Ana María Gómez

Published: June 6, 2011
https://doi.org/10.1371/journal.pone.0020863

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