Ex Vivo Treatment with a Novel Synthetic Aminoglycoside NB54 in Primary Fibroblasts from Rett Syndrome Patients Suppresses MECP2 Nonsense Mutations

Open Access

Peer-reviewed

Research Article

Manuela Vecsler ,

Contributed equally to this work with: Manuela Vecsler, Bruria Ben Zeev

Affiliations Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Bruria Ben Zeev ,

Contributed equally to this work with: Manuela Vecsler, Bruria Ben Zeev

Affiliation Edmond and Lilly Safra Pediatric Hospital, Sheba Medical Center, Tel Hashomer, Israel
⨯
Igor Nudelman,

Affiliation The Edith and Joseph Fisher Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion – Israel Institute of Technology, Haifa, Israel
⨯
Yair Anikster,

Affiliation Edmond and Lilly Safra Pediatric Hospital, Sheba Medical Center, Tel Hashomer, Israel
⨯
Amos J. Simon,

Affiliation Cancer Research Center, Sheba Medical Center, Tel Hashomer, Israel
⨯
Ninette Amariglio,

Affiliation Cancer Research Center, Sheba Medical Center, Tel Hashomer, Israel
⨯
Gideon Rechavi,

Affiliations Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, Cancer Research Center, Sheba Medical Center, Tel Hashomer, Israel
⨯
Timor Baasov,

Affiliation The Edith and Joseph Fisher Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion – Israel Institute of Technology, Haifa, Israel
⨯
Eva Gak

* E-mail: eva.gak@sheba.health.gov.il

Affiliations Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯

Reader Comments (0)

Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Nonsense mutation
Is the Subject Area "Nonsense mutation" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Protein extraction
Is the Subject Area "Protein extraction" applicable to this article?

Thanks for your feedback.
Structural proteins
Is the Subject Area "Structural proteins" applicable to this article?

Thanks for your feedback.
Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.