Experimental Therapy of Ovarian Cancer with Synthetic Makaluvamine Analog: In Vitro and In Vivo Anticancer Activity and Molecular Mechanisms of Action

Tao Chen; Yi Xu; He Guo; Yanling Liu; Pingting Hu; Xinying Yang; Xiaoguang Li; Shichao Ge; Sadanandan E. Velu; Dwayaja H. Nadkarni; Wei Wang; Ruiwen Zhang; Hui Wang

doi:10.1371/journal.pone.0020729

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Open Access

Peer-reviewed

Research Article

Experimental Therapy of Ovarian Cancer with Synthetic Makaluvamine Analog: In Vitro and In Vivo Anticancer Activity and Molecular Mechanisms of Action

Tao Chen ,

Contributed equally to this work with: Tao Chen, Yi Xu

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Yi Xu ,

Contributed equally to this work with: Tao Chen, Yi Xu

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
He Guo,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Yanling Liu,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Pingting Hu,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Xinying Yang,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Xiaoguang Li,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Shichao Ge,

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Sadanandan E. Velu,

Affiliation Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Dwayaja H. Nadkarni,

Affiliation Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Wei Wang,

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America
⨯
Ruiwen Zhang,

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America
⨯
Hui Wang

* E-mail: huiwang@sibs.ac.cn

Affiliation Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯

Experimental Therapy of Ovarian Cancer with Synthetic Makaluvamine Analog: In Vitro and In Vivo Anticancer Activity and Molecular Mechanisms of Action

Tao Chen,
Yi Xu,
He Guo,
Yanling Liu,
Pingting Hu,
Xinying Yang,
Xiaoguang Li,
Shichao Ge,
Sadanandan E. Velu,
Dwayaja H. Nadkarni

Published: June 6, 2011
https://doi.org/10.1371/journal.pone.0020729

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