Differential Expression of PGC-1α and Metabolic Sensors Suggest Age-Dependent Induction of Mitochondrial Biogenesis in Friedreich Ataxia Fibroblasts

José Luis García-Giménez; Amparo Gimeno; Pilar Gonzalez-Cabo; Francisco Dasí; Arantxa Bolinches-Amorós; Belén Mollá; Francesc Palau; Federico V. Pallardó

doi:10.1371/journal.pone.0020666

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Peer-reviewed

Research Article

Differential Expression of PGC-1α and Metabolic Sensors Suggest Age-Dependent Induction of Mitochondrial Biogenesis in Friedreich Ataxia Fibroblasts

José Luis García-Giménez,

Affiliations Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Fundación del Hospital Clínico Universitat de Valencia, FIHCUV-Incliva, Valencia, Spain
⨯
Amparo Gimeno,

Affiliations Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Fundación del Hospital Clínico Universitat de Valencia, FIHCUV-Incliva, Valencia, Spain
⨯
Pilar Gonzalez-Cabo,

Affiliations Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Instituto de Biomedicina Valencia, Valencia, Spain
⨯
Francisco Dasí,

Affiliation Fundación del Hospital Clínico Universitat de Valencia, FIHCUV-Incliva, Valencia, Spain
⨯
Arantxa Bolinches-Amorós,

Affiliations Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Instituto de Biomedicina Valencia, Valencia, Spain
⨯
Belén Mollá,

Affiliations Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Instituto de Biomedicina Valencia, Valencia, Spain
⨯
Francesc Palau,

Affiliations Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Instituto de Biomedicina Valencia, Valencia, Spain
⨯
Federico V. Pallardó

* E-mail: pallardo@uv.es

Affiliations Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Fundación del Hospital Clínico Universitat de Valencia, FIHCUV-Incliva, Valencia, Spain, Department of Physiology, Medical School, Universitat de València, Valencia, Spain
⨯

Differential Expression of PGC-1α and Metabolic Sensors Suggest Age-Dependent Induction of Mitochondrial Biogenesis in Friedreich Ataxia Fibroblasts

José Luis García-Giménez,
Amparo Gimeno,
Pilar Gonzalez-Cabo,
Francisco Dasí,
Arantxa Bolinches-Amorós,
Belén Mollá,
Francesc Palau,
Federico V. Pallardó

Published: June 7, 2011
https://doi.org/10.1371/journal.pone.0020666

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Cultured fibroblasts
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