The Requirement for Pre-TCR during Thymic Differentiation Enforces a Developmental Pause That Is Essential for V-DJβ Rearrangement

Karen S. Hathcock; Lila Farrington; Irina Ivanova; Ferenc Livak; Roza Selimyan; Ranjan Sen; Joy Williams; Xuguang Tai; Richard J. Hodes

doi:10.1371/journal.pone.0020639

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Open Access

Peer-reviewed

Research Article

The Requirement for Pre-TCR during Thymic Differentiation Enforces a Developmental Pause That Is Essential for V-DJβ Rearrangement

Karen S. Hathcock ,

* E-mail: hathcock@exchange.nih.gov

Affiliation Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Lila Farrington,

Affiliation Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Irina Ivanova,

Affiliation Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Ferenc Livak,

Affiliation Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Roza Selimyan,

Affiliation Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Ranjan Sen,

Affiliation Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Joy Williams,

Affiliation Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Xuguang Tai,

Affiliation Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Richard J. Hodes

Affiliations Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯

The Requirement for Pre-TCR during Thymic Differentiation Enforces a Developmental Pause That Is Essential for V-DJβ Rearrangement

Karen S. Hathcock,
Lila Farrington,
Irina Ivanova,
Ferenc Livak,
Roza Selimyan,
Ranjan Sen,
Joy Williams,
Xuguang Tai,
Richard J. Hodes

Published: June 3, 2011
https://doi.org/10.1371/journal.pone.0020639

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Cell differentiation
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Thymocytes
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Polymerase chain reaction
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Developmental signaling
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