Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy

Protim Sarker; Sultan Ahmed; Snigdha Tiash; Rokeya Sultana Rekha; Roger Stromberg; Jan Andersson; Peter Bergman; Gudmundur H. Gudmundsson; Birgitta Agerberth; Rubhana Raqib

doi:10.1371/journal.pone.0020637

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Open Access

Peer-reviewed

Research Article

Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy

Protim Sarker,

Affiliations International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Sultan Ahmed,

Affiliation International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh
⨯
Snigdha Tiash,

Affiliation International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh
⨯
Rokeya Sultana Rekha,

Affiliations International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Roger Stromberg,

Affiliation Department of Biosciences and Nutrition, Center for Infectious Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
⨯
Jan Andersson,

Affiliation Department of Medicine, Center for Infectious Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
⨯
Peter Bergman,

Affiliations Department of Medicine, Center for Infectious Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
⨯
Gudmundur H. Gudmundsson,

Affiliation Institute of Biology, University of Iceland, Reykjavik, Iceland
⨯
Birgitta Agerberth ,

Contributed equally to this work with: Birgitta Agerberth, Rubhana Raqib

Affiliation Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Rubhana Raqib

Contributed equally to this work with: Birgitta Agerberth, Rubhana Raqib

* E-mail: rubhana@icddrb.org

Affiliation International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh
⨯

Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy

Protim Sarker,
Sultan Ahmed,
Snigdha Tiash,
Rokeya Sultana Rekha,
Roger Stromberg,
Jan Andersson,
Peter Bergman,
Gudmundur H. Gudmundsson,
Birgitta Agerberth,
Rubhana Raqib

Published: June 3, 2011
https://doi.org/10.1371/journal.pone.0020637

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Shigellosis
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Rectum
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