Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

Open Access

Peer-reviewed

Research Article

Saran Feng,

Affiliations Leukemia Research Unit, Jiangsu Institute of Hematology, 1st Affiliated Hospital, Soochow University, Key Laboratory of Thrombosis and Hemostasis Ministry of Health, Suzhou, China, Department of Hematology, Xuzhou Central Hospital, Xuzhou, China
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Jiannong Cen,

Affiliation Leukemia Research Unit, Jiangsu Institute of Hematology, 1st Affiliated Hospital, Soochow University, Key Laboratory of Thrombosis and Hemostasis Ministry of Health, Suzhou, China
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Yihong Huang,

Affiliation Department of Hematology, Affiliated Hospital, Xuzhou Medical College, Xuzhou, China
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Hongjie Shen,

Affiliation Leukemia Research Unit, Jiangsu Institute of Hematology, 1st Affiliated Hospital, Soochow University, Key Laboratory of Thrombosis and Hemostasis Ministry of Health, Suzhou, China
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Li Yao,

Affiliation Leukemia Research Unit, Jiangsu Institute of Hematology, 1st Affiliated Hospital, Soochow University, Key Laboratory of Thrombosis and Hemostasis Ministry of Health, Suzhou, China
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Yuanyuan Wang,

Affiliation Leukemia Research Unit, Jiangsu Institute of Hematology, 1st Affiliated Hospital, Soochow University, Key Laboratory of Thrombosis and Hemostasis Ministry of Health, Suzhou, China
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Zixing Chen

* E-mail: szchenzx@263.net

Affiliation Leukemia Research Unit, Jiangsu Institute of Hematology, 1st Affiliated Hospital, Soochow University, Key Laboratory of Thrombosis and Hemostasis Ministry of Health, Suzhou, China
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Leukemia
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Central nervous system
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Mouse models
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Cell disruption
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Blood-brain barrier
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Cancer treatment
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Permeability
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Small interfering RNA
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