Efficient Targeting of Head and Neck Squamous Cell Carcinoma by Systemic Administration of a Dual uPA and MMP-Activated Engineered Anthrax Toxin

Jeffrey M. Schafer; Diane E. Peters; Thomas Morley; Shihui Liu; Alfredo A. Molinolo; Stephen H. Leppla; Thomas H. Bugge

doi:10.1371/journal.pone.0020532

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Peer-reviewed

Research Article

Efficient Targeting of Head and Neck Squamous Cell Carcinoma by Systemic Administration of a Dual uPA and MMP-Activated Engineered Anthrax Toxin

Jeffrey M. Schafer ,

Contributed equally to this work with: Jeffrey M. Schafer, Diane E. Peters, Thomas Morley

Affiliation Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Diane E. Peters ,

Contributed equally to this work with: Jeffrey M. Schafer, Diane E. Peters, Thomas Morley

Affiliations Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America, Program of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Thomas Morley ,

Contributed equally to this work with: Jeffrey M. Schafer, Diane E. Peters, Thomas Morley

Affiliation Bacterial Toxins and Therapeutics Section, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Shihui Liu,

Affiliation Bacterial Toxins and Therapeutics Section, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Alfredo A. Molinolo,

Affiliation Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Stephen H. Leppla,

Affiliation Bacterial Toxins and Therapeutics Section, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Thomas H. Bugge

* E-mail: thomas.bugge@nih.gov

Affiliation Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Efficient Targeting of Head and Neck Squamous Cell Carcinoma by Systemic Administration of a Dual uPA and MMP-Activated Engineered Anthrax Toxin

Jeffrey M. Schafer,
Diane E. Peters,
Thomas Morley,
Shihui Liu,
Alfredo A. Molinolo,
Stephen H. Leppla,
Thomas H. Bugge

Published: May 31, 2011
https://doi.org/10.1371/journal.pone.0020532

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Toxins
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Cancers and neoplasms
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Cancer treatment
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Head and neck squamous cell carcinoma
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Anthrax
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