IL-17RA Is Required for CCL2 Expression, Macrophage Recruitment, and Emphysema in Response to Cigarette Smoke

Kong Chen; Derek A. Pociask; Jeremy P. McAleer; Yvonne R. Chan; John F. Alcorn; James L. Kreindler; Matthew R. Keyser; Steven D. Shapiro; A. McGarry Houghton; Jay K. Kolls; Mingquan Zheng

doi:10.1371/journal.pone.0020333

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Peer-reviewed

Research Article

IL-17RA Is Required for CCL2 Expression, Macrophage Recruitment, and Emphysema in Response to Cigarette Smoke

Kong Chen,

Affiliation Department of Genetics, Louisiana State University Health Science Center, New Orleans, Louisiana, United States of America
⨯
Derek A. Pociask,

Affiliation Department of Genetics, Louisiana State University Health Science Center, New Orleans, Louisiana, United States of America
⨯
Jeremy P. McAleer,

Affiliation Department of Genetics, Louisiana State University Health Science Center, New Orleans, Louisiana, United States of America
⨯
Yvonne R. Chan,

Affiliation Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
John F. Alcorn,

Affiliation Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
James L. Kreindler,

Affiliation Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Matthew R. Keyser,

Affiliation DNASTAR, Madison, Wisconsin, United States of America
⨯
Steven D. Shapiro,

Affiliation Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
A. McGarry Houghton,

Affiliation Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Jay K. Kolls ,

* E-mail: jkolls@lsuhsc.edu

Affiliation Department of Genetics, Louisiana State University Health Science Center, New Orleans, Louisiana, United States of America
⨯
Mingquan Zheng

Affiliation Department of Genetics, Louisiana State University Health Science Center, New Orleans, Louisiana, United States of America
⨯

IL-17RA Is Required for CCL2 Expression, Macrophage Recruitment, and Emphysema in Response to Cigarette Smoke

Kong Chen,
Derek A. Pociask,
Jeremy P. McAleer,
Yvonne R. Chan,
John F. Alcorn,
James L. Kreindler,
Matthew R. Keyser,
Steven D. Shapiro,
A. McGarry Houghton,
Jay K. Kolls

Published: May 27, 2011
https://doi.org/10.1371/journal.pone.0020333

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Smoking habits
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Smoking related disorders
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Chronic obstructive pulmonary disease
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T cells
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Gene expression
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Macrophages
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